From Jab to Journey: The Motivation Way to Sustainable Weight Management

Weight Loss Injections: A Popular Start in 2025

In 2025, injectable weight loss medications such as Mounjaro, Trulicity, and Wegovy—classified as GLP-1 receptor agonists—have become widely used across Ireland. These medications help manage blood sugar levels and reduce appetite, making them a common first step for individuals seeking rapid weight loss.

But one crucial question persists: What happens after the injections stop?

Weight Regain: What the Research Says

Recent findings presented at the European Congress on Obesity 2025 indicate a significant trend of weight regain once GLP-1 medications are discontinued:

Average weight loss of 8 kg was typically regained within 10 months post-medication.
Higher-dose users (e.g., Wegovy, Mounjaro) initially lost up to 16 kg but regained approximately 9.6 kg within a year.
Compared to traditional diet-based weight loss, which often sees gradual regain over 5 years, the post-medication rebound tends to happen much faster.

Why does this happen?
Factors contributing to the regain include the cessation of appetite suppression, medication costs, potential side effects, and lack of long-term psychological support.

Source: The Guardian

Understanding the Underlying Behaviors

While GLP-1 medications address physiological hunger signals, they do not change core eating behaviors or emotional patterns. Common underlying challenges include:

Emotional or stress-related eating
Irregular meal patterns
Lack of daily structure
Ineffective coping strategies for cravings

These behavioral aspects often need to be addressed separately for sustainable weight management.

Exploring Behavioral Support as a Complement

Motivation Weight Management programme incorporate Mental Weight & cognitive behavioral strategies and personalised coaching alongside medication. These approaches focus on helping individuals:

Build awareness of their emotional and psychological relationship with food
Establish routines and habits that promote stability post-medication
Prepare mentally for the transition off GLP-1 support

A 2024 study highlighted that tapering semaglutide in combination with behavioral coaching helped maintain weight loss for at least 26 weeks after stopping the medication.

Source: EASO.org

Key Takeaways

Weight loss injections can offer a helpful kickstart, but sustainable change often requires a more holistic strategy.
Behavioral interventions may play a key role in maintaining progress once medication is phased out.
Understanding one’s “mental weight”—the emotional and psychological factors affecting eating patterns—could be essential in supporting long-term outcomes.